Francesco Zambon, Metamorfosi del Graal

Response to Zambon et al.

Stimulated by our 2015 Current Biology paper [1], Zambon et al. reinvestigated how three myosin isoforms participate in the formation and constriction of the contractile ring in fission yeast. Our paper presented evidence that these myosin isoforms have distinct roles: "Conventional myosin-II Myo2 is crucial to ring assembly, unconventional myosin-II Myp2 is most important for ring constriction...

L-GRAAL: Lagrangian graphlet-based network aligner

MOTIVATION Discovering and understanding patterns in networks of protein-protein interactions (PPIs) is a central problem in systems biology. Alignments between these networks aid functional understanding as they uncover important information, such as evolutionary conserved pathways, protein complexes and functional orthologs. A few methods have been proposed for global PPI network alignments, ...

Francesco Boato

Francesco Blast

Hog thyroid tautomerase (EC 5.3.2.1, phenylpyruvate keto-enol isomerase), an enzyme which is believed to play a role in the biosynthesis of thyroxine, has been purified over lOOO-fold. The purification procedure involves a heat step at 70”, gel f&ration on Sephadex G-100, ion exchange chromatography on carboxymethyl Sephadex C-50, and, finally, gel titration on Sephadex G-50. The enzyme is homo...

De Francesco 8 pages

Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to come because of the chronic nature of the infection, its high prevalence and the significant morbidity of the resulting disease. Recently, a small number of molecules have produced encouraging results in proof-of-concept clinical trials. At the same time, preclinical evidence is accumulating that develo...